Publications

2018

2023

Sousa Silva, M., Roessner, U., Cordeiro, C. (2023) Editorial: Metabolomics in crop research – current and emerging methodologies, volume II. Frontiers in Plant Science - Sec. Plant Metabolism and Chemodiversity 14, 1292878. DOI: 10.3389/fpls.2023.1292878

Sousa Silva, M., Pereira, M., Cruz, M., Gomes, N.G.M., Madureira-Carvalho, A., Cordeiro, C. (2023) The invisible metabolic word of fingermarks revealed by Magnetic Resonance Mass Spectrometry (MRMS). Bruker Application Notes eBook - MRMS 82.

Maia, M., Figueiredo, A., Cordeiro, C., Sousa Silva, M. (2023) FT-ICR-MS-based metabolomics: A deep dive into plant metabolism. Mass Spectrometry Reviews 42(5), 1535-1556 (first published online 20-sept-2021). DOI: 10.1002/mas.21731

Nogues, I., Passatore, L., Bustamante, M.A., Pallozzi, E., Luz, J., Traquete, F., Ferreira, A.E.N., Sousa Silva, M., Cordeiro, C. (2023) Cultivation of Melilotus officinalis as a source of bioactive compounds in association with soil recovery practices. Frontiers in Plant Science (Research Topic: Cover Crops and Green Manures: Providing Services to Agroecosystems) 14, 1218594. DOI: 10.3389/fpls.2023.1218594

Sousa Silva, M., Cordeiro, C. (2023) Autenticidade do vinho: a impressão digital química num token digital não fungível (NFT). Agrotec 48, 24-25. ISSN: 2182-4401

Spano, M., Di Matteo, G., Fernandez Retamozo, C.A., Lasalvia, A., Ruggeri, M., Sandri, G., Cordeiro, C., Sousa Silva, M., Fila, C.T., Garzoli, S., Crestoni, M.E., Mannina, L. (2023) A multimethodological Approach for the Chemical Characterization of Edible Insects: The Case Study of Acheta domesticus. Foods 12(12), 2331. DOI: 10.3390/foods12122331

2022

Sousa Silva, M., Cordeiro, C. (2022) As leveduras vínicas não convencionais na produção de vinho. Agrotec 45, 61-63. ISSN: 2182-4401

Duarte, B., Feijão, E., Cruz de Carvalho, R., Duarte, I.A., Marques, A.P., Maia, M., Hertzog, J., Matos, A.R., Cabrita, M.T., Caçador, I., Figueiredo, A., Sousa Silva, M., Cordeiro, C.*, Fonseca, V.F.* (2022) Untargeted metabolomics reveals anti-depressant effects in a marine photosynthetic organism: the diatom Phaeodactylum tricornutum as a case study. Biology 11(12), 1770. DOI: 10.3390/biology11121770

Maia, M., McCann, A., Malherbe, C., Far, J., Cunha, J., Eiras-Dias, J., Cordeiro, C., Eppe, G., Quinton, L., Figueiredo, A., De Pauw, E.*, Sousa Silva, M.* (2022) Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated to Plasmopara viticola development . Frontiers in Plant Science - Sec. Technical Advances in Plant Science 13, 1012636. DOI: 10.3389/fpls.2022.1012636

Afonso, C.F., Marques, M.C., António, J.M.P., Cordeiro, C., Gois, P.M.P., Cal, P.M.S.D., Bernardes, G.J.L. (2022) Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones. Angewandte Chemie (in press). DOI: 10.1002/anie.202208543

Traquete, F., Luz, J., Cordeiro, C., Sousa Silva, M.*, Ferreira, A.E.N.* (2022) Graph Properties of Mass-Difference Networks for Profiling and Discrimination in Untargeted Metabolomics. Frontiers in Molecular Biosciences 9, 917911. DOI: 10.3389/fmolb.2022.917911

Pinto, D., Gonçalo, R., Louro, M., Silva, M.S., Hernandez, G., Cordeiro, T.N., Cordeiro, C., São-José, C. (2022) On the Occurrence and Multimerization of Two-Polypeptide Phage Endolysins Encoded in Single Genes. Microbiology Spectrum 31, 10(4), e0103722. DOI: 10.1128/spectrum.01037-22

Maia, M., McCann, A., Malherbe, C., Far, J., Cunha, J., Eiras-Dias, J., Cordeiro, C., Eppe, G., Quinton, L., Figueiredo, A., De Pauw, E.*, Sousa Silva, M.* (2022) Grapevine leaf MALDI-MS imaging reveals the localisation of a putatively identified sucrose metabolite associated to Plasmopara viticola development . bioRxiv 2022.08.01.502001. DOI: 10.1101/2022.08.01.502001

Saraiva, M.A., Florêncio, M.H. (2022) Buffering capacity is determinant for restoring early α-synuclein aggregation. Biophysical Chemistry 282, 106760. DOI: 0.1016/j.bpc.2022.106760

2021

Traquete, F., Luz, J., Cordeiro, C., Sousa Silva, M.*, Ferreira, A.E.N.* (2021) Binary Similarity Measures as Effective Tools in Metabolomics Data Analysis. Metabolites (special issue: Data Science in Metabolomics) 2021, 11, 788. DOI: 10.3390/metabo11110788

Sousa Silva, M., Cordeiro, C. (2021) A complexidade num copo de vinho revelada pela espectrometria de massa. Agrotec 40, 61-63. ISSN 2182-4401

Sousa Silva, M., Luz, J., Pendão, A.S., Cordeiro, C. (2021) Magnetic Resonance Mass Spectrometry (MRMS) discriminates yeast mutants through metabolomics. Bruker Application Note, MRMS 75

Sebastiana, M., Gargallo-Garriga, A., Sardans, J., Pérez-Trujillo, M., Monteiro, F., Figueiredo, A., Maia, M., Nascimento, R., Sousa Silva, M., Ferreira, A.N., Cordeiro, C., Marques, A.P., Sousa, L., Malhó, R., Peñuelas, J. (2021) Metabolomics and transcriptomics to decipher molecular mechanisms underlying ectomycorrhizal root colonization of an oak tree. Scientific Reports 11, 8576. DOI: 10.1038/s41598-021-87886-5

Duarte, B., Gameiro, C., Matos, A.R., Figueiredo, A., Sousa Silva, M., Cordeiro, C., Caçador, I., Reis-Santos, P., Fonseca, V., Cabrita, T. (2021) First screening of Biocides, Persistent Organic Pollutants, Pharmaceutical and Personal Care Products in Antarctic phytoplankton from Deception Island by FT-ICR-MS. Chemosphere 274, 129860. DOI: 10.1016/j.chemosphere.2021.129860

Figueiredo, J., Cavaco, A.R., Guerra‐Guimarães, L., Leclercq, C., Renaut, J., Cunha, J., Eiras‐Dias, J., Cordeiro, C., Matos, A.R., Sousa Silva, M., Figueiredo, A. (2021) An apoplastic fluid extraction method for the characterization of grapevine leaves proteome and metabolome from a single sample. Physiologia Plantarum 171, 343-357. doi: 10.1111/ppl.13198

Maia, M.*, Ferreira, A.E.N., Cunha, J., Eiras-Dias, J.E., Cordeiro, C., Figueiredo, A.*, Sousa Silva, M.* (2021) Comparison of the chemical diversity of Vitis rotundifolia and Vitis vinifera cv. ‘Cabernet sauvignon’. Ciência e Técnica Vitivinicola 36 (1), 1-8. DOI: 10.1051/ctv/20213601001

Ferreira, A.E.N., Sousa Silva, M., Cordeiro, C. (2021) Metabolic Network Inference from Time Series. In: Wolkenhauer, Olaf (ed.), Systems Medicine: Integrative, Qualitative and Computational Approaches. vol.3, pp. 127–133. Oxford: Elsevier. doi: 10.1016/B978-0-12-801238-3.11347-9

2020

Ingallina, C., Maccelli, A., Spano, M., Di Matteo, G., Di Sotto, A., Giusti, A.M., Vinci, G., Di Giacomo, S., Rapa, M., Ciano, S., Fraschetti, C., Filippi, A., Simonetti, G., Cordeiro, C., Sousa Silva, M., Crestoni, M.E.*, Sobolev, A.P.*, Fornarini, S., Mannina, L. (2020) Chemico-biological characterization of Torpedino di Fondi® tomato fruits: a comparison with San Marzano cultivar at two ripeness stages. Antioxidants (Section: Natural and Synthetic Antioxidants; Special Issue: "The Potential of Dietary Antioxidants") 9(10), 1027. DOI: 10.3390/antiox9101027

Maia, M., Ferreira, A.E.N., Nascimento, R., Monteiro, F., Traquete, F., Marques, A.P., Cunha, J., Eiras-Dias, J.E., Cordeiro, C., Figueiredo, A.*, Sousa Silva, M.* (2020) Integrating metabolomics and targeted gene expression to uncover potential biomarkers of fungal/oomycetes-associated disease susceptibility in grapevine. Scientific Reports 10, 15688. DOI: 10.1038/s41598-020-72781-2

Figueiredo, J., Cunha, J., Eiras-Dias, J., Sousa Silva, M.*, Figueiredo A.* (2020) Pathogen-related specificity of subtilase VVISBT4.19 X1 in the Vitis vinifera defence response. Ciência Técnica Vitivinicola 35 (1), 42 - 48. doi: 10.1051/ctv/20203501042

Oliveira, B.L., Stenton, B.J., Unnikrishnan, V.B., Almeida, C.R., Conde, J., Negrão, M., Schneider, F.S.S., Cordeiro, C., Ferreira, M.G., Caramori, G.F., Domingos, J.B., Fior, R., Bernardes , G.J.L. (2020) Platinum-Triggered Bond-Cleavage of Pentynoyl Amide and N-Propargyl Handles for Drug-Activation. Journal of the American Chemical Society 142 (24), 10869-10880. doi: 10.1021/jacs.0c01622

Mahú, I., Barateiro, A., Rial-Pensado, E., Martinéz-Sánchez, N., Vaz, S.H., Cal, P.M.S.D., Jenkins, B., Rodrigues, T., Cordeiro, C., Costa, M.F., Mendes, R., Seixas, E., Pereira, M.M.A., Kubasova, N., Gres, V., Morris, I., Temporão, C., Olivares, M., Sanz, Y., Koulman, A., Corzana, F., Sebastião, A.M., López, M., Bernardes, G.J.L., Domingos, A.I. (2020) Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects. Cell Metabolism 31 , 1120 - 1135.e7. doi: 10.1016/j.cmet.2020.04.013

Sousa Silva, M., Cordeiro, C. (2020) Impressão digital química da vinha e do vinho - História e Arte. Agrotec 35, 76-78. ISSN: 2182-4401

Osawa, R.A., Monteiro, O.C., Florêncio, M.H. (2020) Comparative study on photocatalytic degradation of the antidepressant trazodone using (Co, Fe and Ru) doped titanate nanowires: Kinetics, transformation products and in silico toxicity assessment. Chemosphere (in press) Available online 1 July 2020, 127486. doi: 10.1016/j.chemosphere.2020.127486

Rodrigues, A.M., Falé, P.L.V., Madeira P., Pacheco R., Florêncio, M.H., Ascensão L., Serralheiro, M.L.M. (2020) Phenolic profile and biological activities of decoctions from Santolina impressa, a Portuguese endemic species. Journal of Herbal Medicine. 21. doi: 10.1016/j.Hermed.2020.100335

2019

Sousa Silva, M.*, Cordeiro, C., Roessner, U., Figueiredo, A.* (2019) Editorial: Metabolomics in Crop Research - Current and Emerging Methodologies. Frontiers in Plant Science 10: 1013. doi: 10.3389/fpls.2019.01013

Cavaco, A.R., Figueiredo, J., Laureano, G., Sousa Silva, M., Matos, A.R. and Figueiredo, A. (2019). Subtilisin-like proteins and lipid signalling events: the missing links in grapevine resistance to Plasmopara viticola. Acta Horticulturae 1248, 567-574 . doi: 10.17660/ActaHortic.2019.1248.76

Maia, M., Maccelli, A., Nascimento, R., Ferreira, A.E.N., Crestoni, M.E., Cordeiro, C., Figueiredo, A.*, Sousa Silva, M.* (2019) Early detection of Plasmopara viticola infected leaves through FT-ICR-MS metabolic profiling. Acta Horticulturae 1248, 575-580

doi: 10.17660/ActaHortic.2019.1248.77

Osawa, R.A., Barrocas, BT., Monteiro, O.C., Oliveira, M.C., Florêncio, M.H. (2019) Photocatalytic degradation of cyclophosphamide and ifosfamide: Effects of wastewater matrix, transformation products and in silico toxicity prediction. Journal of the Total Environment (2019). doi:10.1016/j.scitotenv.2019.07.247

Maia, M., Ferreira, A.E.N., Laureano, G., Marques, A.P., Torres, V.M., Silva, A.B., Matos, A.R., Cordeiro, C., Figueiredo, A.*, Sousa Silva, M.* (2019) Vitis vinifera ‘Pinot Noir’ leaves as a source of bioactive nutraceutical compounds. Food & Function 10 (7): 3822-3827. doi: 10.1039/c8fo02328j

Osawa, R.A., Barrocas, BT., Monteiro, O.C., Oliveira, M.C., Florêncio, M.H., 2019. Photocatalytic degradation of amitriptyline, trazodone and venlafaxine using modified cobalt-titanate nanowires under UV−Vis radiation: Transformation products and in silico toxicity. Chemical Engineering Journal 373: 1338-1347. doi: 10.1016/j.cej.2019.05.137

Assis, A.C.A., Caetano, J., Florêncio, M.H., Cordeiro, C. (2019) Triacetone triperoxide characterization by FT-ICR mass spectrometry: Uncovering multiple forensic evidence. Forensic Science International 301: 37-45. doi: 10.1016/j.forsciint.2019.04.020

Osawa, R.A., Carvalho, A.P., Monteiro, O.C., Oliveira, M.C., Florêncio, M.H. (2019) Degradation of duloxetine: Identification of transformation ptroducts by UHPLC-ESI(+)-HRMS/MS, in silico toxicity and waste water analysis. Journal of Environmental Sciences 82: 113-123. doi: 10.1016/j.jes.2019.02.025

Nascimento, R., Maia, M., Ferreira, A.E.N., Silva, A.B., Freire, A.P., Cordeiro, C., Sousa Silva, M.*, Figueiredo, A.* (2019) Early stage metabolic events associated with the establishment of Vitis vinifera - Plasmopara viticola compatible interaction. Plant Physiology and Biochemistry 137: 1-13. doi: 10.1016/j.plaphy.2019.01.026

Osawa, R.A., Carvalho, A.P., Monteiro, O.C., Oliveira, M.C., Florêncio, M.H. (2019) Transformation products of citalopram: Identification and in-silico toxicological assessment. Chemosphere 217: 858-868. doi: 10.1016/j.chemosphere.2018.11.027

Sun, S., Akkapeddi, P., Marques, M.F., Martinez, N., Torres, V.M., Cordeiro, C., Boutureira, O., Bernardes, G. (2019) One-pot stapling of interchain disulfides of antibodies using an isobutylene motif. Organic & Biomolecular Chemistry 2019, 17, 2005-2012. doi: 10.1039/C8OB02877J

2018

Maia, M., Ferreira, A., Marques, A.P., Figueiredo, J., Freire, A.P., Cordeiro, C., Figueiredo, A.*, Sousa Silva, M.* (2018) Uncovering markers for mildew resistance in grapevine through mass spectrometry-based metabolomics. Revista de Ciências Agrárias 41(Especial): 48-53. doi: 10.19084/RCA17334

Figueiredo, A., Figueiredo, J., Maia, M., Cavaco, A.R., Laureano, G., Nascimento, R., da Silva, C., Matos, A.R., Sousa Silva, M. (2018) Subtilisin-like proteases and lipid signalling events play an important role in grapevine resistance to downy mildew: a systems biology approach. Revista de Ciências Agrárias 41 (Especial): 61-66. doi: 10.19084/RCA17325

Figueiredo, J., Laureano, G., da Silva, C., Maia, M., Sousa Silva, M.*, Figueiredo, A.* (2018) Assessing the link between subtilases and lipid signaling events in grapevine downy mildew resistance. Revista de Ciências Agrárias 41(Especial): 54-60. doi: 10.19084/RCA17330

Laureano, G., Figueiredo, J., Cavaco, A.R., Duarte, B., Caçador, I., Malhó, R., Sousa Silva, M., Matos, A.R., Figueiredo, A. (2018) The interplay between membrane lipids and phospholipase A family members in grapevine resistance against Plasmopara viticola. Scientific Reports 8: 14538. doi: 10.1038/s41598-018-32559-z

Lamy, E., Neves, S., Ferreira, J., Rodrigues, L., da Costa, G., Cordeiro, C., Fialho, L., Lima, M., Costa, A.R., Antunes, C.M., Lopes, O., Amado, F., Capela E Silva F. (2018) Effects of hyperleptinemia in rat saliva composition, histology and ultrastructure of the major salivary glands. Archives of Oral Biology 96: 1-12. doi: 10.1016/j.archoralbio.2018.08.005

Piedade C.A., Sousa Silva M., Cordeiro C., Ferreira A.E.N. (2018) Virus Disassembly Pathways Predicted from Geometry and Configuration Energy. In: Peixoto N., Silveira M., Ali H., Maciel C., van den Broek E. (eds) Biomedical Engineering Systems and Technologies. BIOSTEC 2017. Communications in Computer and Information Science, vol 881. Springer, Cham. doi: 10.1007/978-3-319-94806-5_16

O’Caoimh, R., Molloy, D.W., Fitzgerald, C., Van Velsen, L., Cabrita, M., Nassabi, M.H., de Vette, F., Dekker-van Weering, M., Jansen-Kosterink, S., Kenter, W., Frazer, S., Rauter, A.P., Turkman, A., Antunes, M., Turkman, F., Silva, M.S., Martins, A., Costa, H.S., Albuquerque, T.G., Ferreira, A., Scherillo, M., De Luca, V., Illario, M., García A., Sanchez Carrion, R., Gómez Aguilera, E.J., Solana Sánchez, J., Hermans, H., Vollenbroek-Hutten, M. (2018) ICT-Supported Interventions Targeting Pre-frailty: Healthcare Recommendations from the Personalised ICT Supported Service for Independent Living and Active Ageing (PERSSILAA) Study. In: Röcker C., O’Donoghue J., Ziefle M., Maciaszek L., Molloy W. (eds) Information and Communication Technologies for Ageing Well and e-Health. ICT4AWE 2017. Communications in Computer and Information Science, vol 869. Springer, Cham. doi: 10.1007/978-3-319-93644-4_4

Figueiredo, J., Sousa Silva, M.*, Figueiredo, A.* (2018) Subtilisin-like proteases in plant defence: the past, the present and beyond. Molecular Plant Pathology 19: 1017–1028. doi: 10.1111/mpp.12567

Henriques J., Falé P., Pacheco R., Florêncio M.H., Serralheiro M.L. (2018) Phenolic compounds from Actinidia deliciosa leaves: Caco-2 permeability, enzyme inhibitory activity and cell protein profile studies. Journal of King Saud University – Science 30: 513-518. doi: 10.1016/j.jksus.2017.07.007

2017

Rodrigues, L., da Costa, G., Cordeiro, C., Pinheiro, C.C., Amado, F., Lamy, E. (2017) Relationship between saliva protein composition and 6-n-Propylthiouracil bitter taste responsiveness in young adults. Journal of Sensory Studies 32(4): Article nr e12275- doi: 10.1111/joss.12275

Figueiredo, J., Maia, M., Sousa Silva, M.*, Figueiredo, A.* (2017) Grapevine subtilase family: update on new sequences and nomenclature proposal. Frontiers in Plant Science 8: 716. doi: 10.3389/fpls.2017.00716

Piedade C., Ferreira A. and Cordeiro C. (2017). How to Disassemble a Virus Capsid – A Computational Approach. In: Proceedings of the 10th International Joint Conference on Biomedical Engineering Systems and Technologies – Volume 3: BIOINFORMATICS, (BIOSTEC 2017), 217-222. ISBN: 978-989-758-214-1. doi: 10.5220/0006249802170222

O’Caoimh, R., Molloy, D.W., Fitzgerald, C., Van Velsen, L., Cabrita, M., Nassabi, M.H., de Vette, F., Dekker-van Weering, M., Jansen-Kosterink, S., Kenter, W., Frazer, S., Rauter, A.P., Turkman, A., Antunes, M., Turkman, F., Silva, M.S., Martins, A., Costa, H.S., Albuquerque, T.G., Ferreira, A., Scherillo, M., De Luca, V., Illario, M., García A., Sanchez Carrion, R., Gómez Aguilera, E.J., Solana Sánchez, J., Hermans, H., Vollenbroek-Hutten, M. (2017) Healthcare Recommendations from the PERsonalised ICT Supported Service for Independent Living and Active Ageing (PERSSILAA) study. (Conference Paper) In: Proceedings of the 3rd International Conference on Information and Communication Technologies for Ageing Well and e-Health (ICT4AWE 2017), 91-103. ISBN: 978-989-758-251-6

Vicente Miranda H, Szego ÉM, Oliveira LM, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF (2017) Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies. Brain 140(5): 1399-1419. doi: 10.1093/brain/awx056

2016

Figueiredo, J., Costa, G., Maia, M., Paulo, O., Malhó, R., Sousa Silva, M.*, Figueiredo, A.* (2016) Revisiting Vitis vinífera subtilase gene family: a possible role in grapevine resistance against Plasmopara viticola. Frontiers in Plant Science 7: 1783. doi: 10.3389/fpls.2016.01783

Guerreiro, A., Figueiredo, J., Sousa Silva, M.*, Figueiredo, A.* (2016) Linking jasmonic acid to grapevine resistance against the biotrophic oomycete Plasmopara viticola. Frontiers in Plant Science – Special Research Topic on “Biotrophic plant-microbe interactions” 7, 565. doi: 10.3389/fpls.2016.00565

Maia, M., Monteiro, F., Sebastiana, M., Marques, A.P., Ferreira, A.E.N., Ponces Freire, A., Cordeiro, C., Figueiredo, A.*, Sousa Silva, M.* (2016) Metabolite extraction for high-throughput FTICR-MS-based metabolomics in grapevine. EuPA Open Proteomics 12: 4-9. doi: 10.1016/j.euprot.2016.03.002

Fonseca, D, Gilberto, S., Ribeiro-Silva, C., Ribeiro, R., Guinote, I.B., Saraiva, S., Gomes, R.A., Mateus, E., Viana, A., Barroso, E., Freire, A.P., Freire, P., Cordeiro, C., Da Costa, G. (2016) The role of fibrinogen glycation in ATTR: Evidence for chaperone activity loss in disease. Biochemical Journal 473, 2225-2237

Lebesgue N, da Costa G, Ribeiro RM, Ribeiro-Silva C, Martins GG, Matranga V, Scholten A, Cordeiro C, Heck AJ, Santos R. (2016) Deciphering the molecular mechanisms underlying sea urchin reversible adhesion: A quantitative proteomics approach. Journal of Proteomics 138, 61-71. doi: 10.1016/j.jprot.2016.02.026

Lebesgue N., da Costa G., Ribeiro R.M., Ribeiro-Silva C., Martins G.G., Matranga V., Scholten A., Cordeiro C., Heck A.J., Santos R. (2016) Proteomic dataset of the sea urchin Paracentrotus lividus adhesive organs and secreted adhesive. Data Brief. 7: 1497-505. doi: 10.1016/j.dib.2016.04.002

Toubarro D., Gouveia A., Ribeiro R.M., Simões N., da Costa G., Cordeiro C., Santos R. (2016) Cloning, Characterization, and Expression Levels of the Nectin Gene from the Tube Feet of the Sea Urchin Paracentrotus lividus. Marine Biotechnology (NY). 18(3): 372-83. doi: 10.1007/s10126-016-9698-4

Vilas-Boas F, Bagulho A, Tenente R, Teixeira VH, Martins G, da Costa G, Jerónimo A, Cordeiro C, Machuqueiro M, Real C. (2016) Hydrogen peroxide regulates cell adhesion through the redox sensor RPSA. Free Radic Biol Med. 90, 145-57. doi: 10.1016/j.freeradbiomed.2015.11.019. (Epub 2015, Nov 18)

Marques A.P., Serralheiro M.L., Ferreira A.E., Freire A.P., Cordeiro C., Sousa Silva M. (2016) Metabolomics for undergraduates: Identification and pathway assignment of mitochondrial metabolites. Biochem Mol Biol Educ. 44(1), 38-54. doi: 10.1002/bmb.20919. (Epub 2015, Nov 5)

2015

Oliveira BL, Morais M, Mendes F, Moreira IS, Cordeiro C, Fernandes PA, Ramos MJ, Alberto R, Santos I, Correia JD. (2015) Re(I) and Tc(I) complexes for targeting nitric oxide synthase: influence of the chelator in the affinity for the enzyme. Chem Biol Drug Des. 86(5), 1072-86. doi: 10.1111/cbdd.12575

Gaspar H, Bronze S, Ciríaco S, Queirós CR, Matias A, Rodrigues J, Oliveira C, Cordeiro C, Santos S. (2015) 4F-PBP (4′-fluoro-α-pyrrolidinobutyrophenone), a new substance of abuse: Structural characterization and purity NMR profiling. Forensic Sci Int. 252, 168-76. doi: 10.1016/j.forsciint.2015.05.003

Cal PM, Frade RF, Cordeiro C, Gois PM. (2015) Reversible lysine modification on proteins by using functionalized boronic acids. Chemistry 21(22),8182-7. doi: 10.1002/chem.201500127

da Costa G, Ribeiro-Silva C, Ribeiro R, Gilberto S, Gomes RA, Ferreira A, Mateus É, Barroso E, Coelho AV, Freire AP, Cordeiro C. (2015) Transthyretin Amyloidosis: Chaperone Concentration Changes and Increased Proteolysis in the Pathway to Disease. PLoS One 10(7), e0125392. doi: 10.1371/journal.pone.0125392

2014

Cardoso LS, Suissas CE, Ramirez M, Antunes M, Pinto FR (2014) Comparison of alternative mixture model methods to analyze bacterial CGH experiments with multi-genome arrays. BMC Res Notes., 7, 148

Simões RG, Diogo HP, Dias A, Oliveira MC, Cordeiro C, Bernardes CE, Minas Da Piedade ME. (2014) Thermal stability of simvastatin under different atmospheres. J Pharm Sci., 103, 241-248

Cal PM, Frade RF, Chudasama V, Cordeiro C, Caddick S, Gois PM. (2014) Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates. Chem Commun (Camb) 50, 5261-5263

Teixeira, B., Fidalgo, L., Mendes, R., Costa, G., Cordeiro, C., Marques, A., Saraiva, J.A., Nunes, M.L. (2014) Effect of high pressure processing in the quality of sea bass (Dicentrarchus labrax) fillets: Pressurization rate, pressure level and holding time. Journal of Innovative Food Science and Emerging Technologies, 22, 31-39

Trübenbach K, da Costa G, Ribeiro-Silva C, Mesquita Ribeiro R, Cordeiro C, Rosa R (2014) Hypoxia-driven selective degradation of cellular proteins in jumbo squids during diel migration to the oxygen minimum zones. Marine Biology, 161, 575-584

Carrolo M, Pinto FR, Melo-Cristino J, Ramirez M. (2014) Pherotype influences biofilm growth and recombination in Streptococcus pneumoniae. PLoS One. 2014 Mar 19;9(3):e92138. doi: 10.1371/journal.pone.0092138

2013

Sousa Silva, M., Gomes, R.A., Ferreira, A.E.N., Ponces Freire, A., Cordeiro, C. (2013) The glyoxalase pathway: The first hundred years… and beyond. Biochemical Journal 453(1): 1-15 (Invited review). DOI: 10.1042/BJ20121743

Meireles, C., Costa, G., Guinote, I., Albuquerque, T., Botelho, A., Cordeiro, C., Freire, P. (2013) Pseudomonas putida are environmental reservoirs of antimicrobial resistance to β-lactamic antibiotics. World Journal Microbiology Biotechnology Feb 19. [Epub ahead of print]. DOI: 10.1007/s11274-013-1295-3

Teixeira, B.,Fidalgo, L., Mendes, R., Costa, G., Cordeiro, C., Marques, A., Saraiva, J.A., Nunes, M.L. (2013) Changes of Enzymes Activity and Protein Profiles Caused by High-Pressure Processing in Sea Bass (Dicentrarchus labrax) Fillets. Journal of Agricultural and Food Chemistry 61(11), 2851-2860. DOI: 10.1021/jf3049643

Martins, A., Santos, M.S., Dias, C., Serra, P., Cachatra, V., Pais, J., Caio, J., Teixeira, V.H., Machuqueiro, M., Silva, M.S., Pelerito, A., Justino, J., Goulart, M., Silva, F.V., Rauter, A.P. (2013) Tuning bioactivity of new tensioactive deoxy glycosides with structure: antibacterial activity vs. selective cholinesterase inhibition rationalized by molecular docking. European Journal of Organic Chemistry 2013(8), 1448-1459. (Special issue dedicated to the centenary of the Portuguese Society of Chemistry – SPQ). DOI: 10.1002/ejoc.201201520

Rivaldi, J.D., Sousa Silva, M., Duarte, L.C., Ferreira, A.E.N., Cordeiro, C., Felipe, M.G.A., Ponces Freire, A., Mancilha, I.M. (2013) Metabolism of biodiesel-derived glycerol in probiotic Lactobacillus strains. Applied Microbiology and Biotechnology. 97(4), 1735-1743. DOI: 10.1007/s00253-012-4621-z

2012

Lages, N.F., Cordeiro, C., Sousa Silva, M., Ponces Freire, A., Ferreira, A.E.N. (2012) Optimization of time-course experiments for kinetic model discrimination. PLoS One, 7(3), e32749, DOI: 10.1371/journal.pone.0032749

Falé, P.L., Amaral, F., Madeira, P.J.A., Sousa Silva, M., Florêncio, M.H., Frazão, F.N., Serralheiro, M.L.M. (2012) Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines. Food and Chemical Toxicology 50(8), 2656-2662, DOI: 10.1016/j.fct.2012.04.049

Sousa Silva, M., Ferreira, A., Gomes, R., Tomás, A., Ponces Freire, A., Cordeiro, C. (2012) The glyoxalase pathway in protozoan parasites. International Journal of Medical Microbiology, 302 (4-5), 225-229 – Special issue “Molecular Principles of Parasitism” (Invited review). DOI: 10.1016/j.ijmm.2012.07.005

Gomes, R.A., Franco, C., Da Costa, G., Planchon, S., Renaut, J., Pinto, F., Sousa Silva, M., Coelho, A.V., Ponces Freire, A., Cordeiro, C. (2012) The proteome response to amyloid protein expression in vivo. PLoS One, 7(11): e50123. DOI:10.1371/journal.pone.0050123

Da Silva, J.P., Kulasekharan, R., Cordeiro, C., Jockusch, S., Turro, N.J., Ramamurthy, V. (2012) Capsular Complexes of Nonpolar Guests with Octa Amine Host Detected in the Gas Phase. Organic Letters. 14(2), 560-563. DOI: 10.1021/ol203139v

Guerreiro, A., da Costa, G., Gomes, R.A., Ribeiro-Silva, C., Gilberto, S., Mateus, E., Monteiro, E., Barroso, E., Coelho, A.V., Freire, A.P., Cordeiro, C. (2012) alpha-Synuclein aggregation in the saliva of familial transthyretin amyloidosis: a potential biomarker. Amyloid, 19(2), 74-80

Cal, P.M., Vicente, J.B., Pires, E., Coelho, A.V., Veiros, L.F., Cordeiro, C., Gois, P.M. (2012) Iminoboronates: a new strategy for reversible protein modification. Journal of the American Chemical Society, 134 (24), 10299-305. DOI: 10.1021/ja303436y

Friães, A., Pinto, F.R., Silva-Costa, C., Ramirez, M., Melo-Cristino, J. (2012) Group A streptococci clones associated with invasive infections and pharyngitis in Portugal present differences in emm types, superantigen gene content and antimicrobial resistance. BMC Microbiology, 12(1), 280

Friães, A., Pinto, F.R., Silva-Costa, C., Ramirez, M., Melo-Cristino, J. (2012) Superantigen gene complement of Streptococcus pyogenes-relationship with other typing methods and short-term stability. European Journal of Clinical Microbiology and Infectious Diseases. E-pub August 2012. DOI: 10.1007/s10096-012-1726-3

Valente, C., Hinds, J., Pinto, F., Brugger, S.D., Gould, K., Muhlemann, K., de Lencastre, H., Sa-Leao, R. (2012) Decrease in Pneumococcal Co-Colonization following Vaccination with the Seven-Valent Pneumococcal Conjugate Vaccine. PLoS One , 7(1), e30235. DOI: 10.1371/journal.pone.0030235

Tendeiro, R., Foxall, R.B., Baptista, A.P., Pinto, F., Soares, R.S., Cavaleiro, R., Valadas, E., Gomes, P., Victorino, R.M.M., Sousa, A.E. (2012) PD-1 and its ligand PD-L1 are progressively up-regulated on CD4 and CD8 T-cells in HIV-2 infection irrespective of the presence of viremia. AIDS, 26(9), 1065-1071. DOI: 10.1097/QAD.0b013e32835374db

Faria, D., Schlicker, A., Pesquita, C., Bastos, H., Ferreira, A.E., Albrecht, M., Falcão, A.O. (2012) Mining GO annotations for improving annotation consistency. PLoS One, 7(7), e40519. DOI: 10.1371/journal.pone.0040519

2011

Da Silva JP, Kulasekharan R, Cordeiro C, Jockusch S, Turro NJ, Ramamurthy V (2011) Capsular Complexes of Nonpolar Guests with Octa Amine Host Detected in the Gas Phase. Org Lett. 2011 Dec 23. [Epub ahead of print]

Severiano A, Pinto FR, Ramirez M, Carriço JA (2011) Adjusted Wallace coefficient as a measure of congruence between typing methods. J Clin Microbiol. 49(11), 3997-4000.

Severiano A, Carriço JA, Robinson DA, Ramirez M, Pinto FR (2011) Evaluation of jackknife and bootstrap for defining confidence intervals for pairwise agreement measures. PLoS One 6(5), e19539. DOI:10.1371/journal.pone.0019539

da Costa G, Gomes RA, Guerreiro A, Mateus É, Monteiro E, Barroso E, Coelho AV, Freire AP, Cordeiro C (2011) Beyond genetic factors in familial amyloidotic polyneuropathy: protein glycation and the loss of fibrinogen’s chaperone activity. PLoS One 6(10), e24850. doi:10.1371/journal.pone.0024850

Ribeiro-Silva C, Gilberto S, Gomes RA, Mateus É, Monteiro E, Barroso E, Coelho AV, da Costa G, Freire AP, Cordeiro C (2011) The relative amounts of plasma transthyretin forms in familial transthyretin amyloidosis: a quantitative analysis by Fourier transform ion-cyclotron resonance mass spectrometry. Amyloid 18(4), 191-9.

Barata L, Sousa Silva M, Schuldt L, Ferreira AEN, Gomes RA, Tomás AM, Weiss MS, Ponces Freire A, Cordeiro C (2011) Enlightening the molecular basis of trypanothione specificity in trypanosomatids: mutagenesis of Leishmania infantum glyoxalase II. Exp Parasitol 129(4), 402-8.

Fortes AM, Agudelo-Romero P, Silva MS, Ali K, Sousa L, Maltese F, Choi YH, Grimplet J, Martinez-Zapater JM, Verpoorte R, Pais MS (2011) Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. BMC Plant Biology 11, 149. doi:10.1186/1471-2229-11-149.

Sá-Leão R, Pinto FR, Aguiar S, Nunes S, Carriço JA, Frazão N, Gonçalves-Sousa N, Melo-Cristino J, de Lencastre H, and Ramirez M (2011) Analysis of invasiveness of pneumococcal serotypes and clones circulating in Portugal before widespread use of conjugate vaccines revealing heterogeneous behavior of clones expressing the same serotype, J Clin Microbiol, 49,1369-75

2010

Barata, L., Sousa Silva, M., Schuldt, L., Tomás, A.M., Ferreira, A.E.N., Weiss, M.S., Ponces Freire, A., Cordeiro, C. (2010) Cloning, Expression, Purification, Crystallization and Preliminary X-ray Diffraction Analysis of Glyoxalase I from Leishmania infantum, Acta Crystallographica Section F 66, 571-4.

da Costa G,. Correia CF, Gomes RJ, Freire A, Monteiro E, Barroso E, Coelho AV , Outeiro TF, Freire AP and Cordeiro C. (2010) A non-invasive method based on saliva to characterize TTR in PAF patients using FT-ICR high-resolution mass spectrometry, Proteomics Clin. Appl. 4, 674-8.

Lamy E, da Costa G, Santos R, Capela E Silva F, Potes J, Pereira A, Coelho AV, Sales Baptista E. (2010) Effect of condensed tannin ingestion in sheep and goat parotid saliva proteome, J Anim Physiol Anim Nutr (Berl), doi: 10.1111/j.1439-0396.2010.01055.x.

Lamy E, Graca G, da Costa G, Franco C, Capela E Silva F, Sales Baptista E, Coelho AV. (2010) Changes in mice whole saliva soluble proteome induced by tannin-enriched diets, Proteome Sci. 15;8(1), 65.

Oliveira BL, Raposinho PD, Mendes F, Santos IC, Santos IS, Ferreira A, Cordeiro C, Freire AP, Correia JDC (2010) Targeting nitric oxide synthase with 99mTc/Re tricarbonyl complexes containing pendant guanidino or isothiourea moieties, J Organometal. Chem., doi:10.1016/j.jorganchem.2010.09.019.

Oliveira BL, Raposinho PD, Mendes F, Figueira A, Santos I, Ferreira A, Cordeiro C, Freire AP, Correia JD (2010) Re and Tc Tricarbonyl Complexes: From the Suppression of NO Biosynthesis in Macrophages to in Vivo Targeting of Inducible Nitric Oxide Synthase, Bioconjug Chem, 21(12), 2168-72.

Carrolo M, Frias MJ, Pinto FR, Melo-Cristino J, Ramirez M. (2010) Prophage Spontaneous Activation Promotes DNA Release Enhancing Biofilm Formation in Streptococcus pneumoniae, PLoS One 5(12), e15678.

Aguiar SI, Pinto FR, Nunes S, Serrano I, Melo-Cristino J, Sá-Leão R, Ramirez M, de Lencastre H (2010) Increase of Denmark14-230 clone as a cause of pneumococcal infection in Portugal within a background of diverse serotype 19A lineages, J Clin Microbiol. 48(1), 101-8

2009

R. Santos, G. da Costa, C. Franco, P. Alves, P. Flammang and A. V. Coelho (2009) First insights into the biochemistry of tube foot adhesives from the sea urchin Paracentrotus lividus, Marine Biotechnol, 11, 686-98.

Toubarro, D., M. Lucena-Robles, G. Nascimento, da Costa G., R. Montiel, A. Coelho, N. Simões (2009) An apoptosis induncing serine protease secreted by the entomopathogenic nematode Steinernema caopocapsa, Int J Parasitol., 39, 1319-30.

Chaves I, Pinheiro C, Paiva JAP, Planchon S, Sergeant K, Renaut J, JGraça JA, da Costa G, Coelho AV, Ricardo CPP (2009) Proteomic evaluation of wound-healing processes in Potato (Solanum tuberosum L.) tuber tissue. Proteomics, 9, 4154-75.

Campos A, da Costa G, Coelho AV and Fevereiro P (2009) Identification of bacterial protein markers and enolase as a plant response protein to infection of Olea europaea L. subsp. europaea by Pseudomonas savastanoi pv savastanoi. Eur J Plant Pathol, 125, 603-16.

Lamy, E., G. Da Costa, R. Santos, F. Capela e Silva, J. Potes, A. Pereira, A.V. Coelho A and E. Sales Baptista (2009) Sheep and goat saliva proteome analysis: a useful tool for ingestive behavior research?, Physiol Behav, 98, 393-40.

Pinto F.R.J (2009) A Probabilistic Approach to Study Yeast’s Gene Regulatory Network. Comput Sci Syst Biol, 2, 044-050.

Carrolo M, Pinto FR, Melo-Cristino J, Ramirez M, (2009) Pherotypes are driving genetic differentiation within Streptococcus pneumonia. BMC Microbiol., 9, 191.

da Costa G, Gomes R, Correia CF, Freire A, Monteiro E, Martins A, Barroso E, Coelho AV, Outeiro TF, Ponces Freire A, Cordeiro C.(2009) Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry. Amyloid. 16, 201-207.

Faria D, Ferreira AE, Falcão AO (2009) Enzyme classification with peptide programs: a comparative study. BMC Bioinformatics, 24, 231

Oliveira B.L., Correia J.D., Raposinho P.D., Santos I., Ferreira A., Cordeiro C., Freire A.P. (2009) Re and 99mTc organometallic complexes containing pendant l-arginine derivatives as potential probes of inducible nitric oxide synthase. Dalton Transactions. Jan 7, 1: 152-162

2008

Pinto F.R., Melo-Cristino J., Ramirez M. (2008) A Confidence Interval for the Wallace Coefficient of Concordance and Its Application to Microbial Typing Methods. PLoS ONE, 3(11):e3696. doi:10.1371/journal.pone.0003696

Fortes A.M., Santos F., Choi Y.H., Silva M.S., Figueiredo A., Sousa L., Pessoa F., Santos B.A., Sebastiana M., Palme K., Malhó R., Verpoorte R., Pais M.S. (2008) Organogenic nodule development in hop (Humulus lupulus L.): transcript and metabolic responses. BMC Genomics. 9: 445.

Gomes R.A, Oliveira L.M., Silva M., Ascenso C, Quintas A., Costa G., Coelho A.V., Sousa Silva M., Ferreira A.E., Ponces Freire A., Cordeiro C.(2008) Protein glycation in vivo: functional and structural effects on yeast enolase. Biochem J, 416: 317-326.

Sousa Silva, M., Barata, L., Ferreira, A.E.N., Romão, S., Tomás, A.M., Ponces Freire, A., Cordeiro, C. (2008) Catalysis and Structural Properties of Leishmania infantum Glyoxalase II: Trypanothione Specificity and Phylogeny, Biochemistry, 47: 195-204. DOI: 10.1021/bi700989m.

Vicente Miranda, H. , Ferreira, A.E.N., Quintas, A., Cordeiro, C., Ponces Freire, A. (2008) Measuring Intracellular Enzyme Concentrations. Biochemical and Molecular Biology Education, 36:135-138.

Ispolnov K., Gomes R.A., Silva M.S., Freire A.P. (2008) Extracellular methylglyoxal toxicity in Saccharomyces cerevisiae: role of glucose and phosphate ions. Journal of Applied Microbiology, 104: 1092-1102.

Gomes, R., Vicente Miranda, H., Sousa Silva, M., Graça, G., Coelho, A. V., Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2008) Protein glycation and methylglyoxal metabolism in yeast: finding peptide needles in protein haystacks. FEMS Yeast Research, 8: 174-181.

2007 and before

Neng, N.R., Cordeiro,C., Ponces Freire, A., Nogueira, J.M.F. (2007) Determination of glyoxal and methylglyoxal in environmental and biological matrices by stir bar sorptive extraction with in situ derivatization. Journal of Cromatography A, 1169: 47-52.

Farinha, C.M., Ponces Freire, A. (2007) Teaching biochemistry at Lisbon University – Facing the challenge of the Bologna Declaration in the 25th anniversary of the biochemistry course. Biochemical and Molecular Biology Education, 35: 422-424.

Oliveira, L.M.A., Cordeiro, C., Ponces Freire, A., Ascenso, C., Quintas, A. (2007) Unveiling heme proteins conformational stability through a UV absorbance ratio method. Analytical Biochemistry, 371: 253-255. abstract

Maia, L., Duarte, R., Moura, J., Ponces Freire, A., Mira, L. (2007) NADH oxidase activity of rat and human liver xanthine oxidoreductase: potential role in superoxide production. Journal of Biological Inorganic Chemistry, 12: 777-787.

Gomes, R., Vicente Miranda, H., Sousa Silva, M., Graça, G., Coelho, A. V., Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2006) Yeast protein glycation in vivo by methylglyoxal Molecular modification of glycolytic enzymes and heat shock proteins. FEBS Journal, 273: 5273-5287

Trincão J., Sousa Silva M., Barata L., Bonifacio C., Carvalho S., Tomas A.M., Ferreira, A.E.N., Cordeiro C., Ponces Freire A., Romao M.J. (2006) Purification, crystallization and preliminary X-ray diffraction analysis of the glyoxalase II from Leishmania infantum. Acta Crystallograph Sect F Struct Biol Cryst Commun. 62: 805-807

Vicente Miranda, H. , Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2005) Kinetic assay for measurement of enzyme concentration in situ. Analytical Biochemistry, 354:148-150.

Gomes, R., Sousa Silva, M., Vicente Miranda, H. , Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2005) Protein glycation in Saccharomyces cerevisiae : Argpyrimidine formation and methylglyoxal catabolism. FEBS Journal , 272(17): 4521-4531.

Abecasis, J.P.R., Ferreira, A.E.N., Vicente Miranda, H. , Gomes, R., Sousa Silva, M., Cordeiro, C., Ponces Freire, A. (2005) Parameter estimation in multi-enzyme systems using evolutionary algorithms. BKDB2005 – Bioinformatics: Knowledge Discovery in Biology . Faculdade de Ciências de Lisboa Ed. pp 48-52.

Sousa Silva, M. , Ferreira, A.E.N., Tomás, A.M., Cordeiro, C., Ponces Freire, A. (2005) Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation. FEBS Journal 272(10): 2388-2398.

do Rosario PM , Cordeiro CA , Freire AP , Nogueira JM (2005) Analysis of methylglyoxal in water and biological matrices by capillary zone electrophoresis with diode array detection. Electrophoresis, 26(9):1760-1767.

Gomes, R., Sousa Silva, M. , Quintas, A., Cordeiro, C., Freire, A., Pereira, P., Martins, A., Monteiro, E., Barroso, E., Ponces Freire, A. (2005) Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy. Biochemical Journal 385: 339-345

Gomes, R., Vicente Miranda, H., Sousa Silva, M., Graça, G., Coelho, A. V., Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2006) Yeast protein glycation in vivo by methylglyoxal Molecular modification of glycolytic enzymes and heat shock proteins. FEBS Journal, 273: 5273-5287

Trincão J., Sousa Silva M., Barata L., Bonifacio C., Carvalho S., Tomas A.M., Ferreira, A.E.N., Cordeiro C., Ponces Freire A., Romao M.J. (2006) Purification, crystallization and preliminary X-ray diffraction analysis of the glyoxalase II from Leishmania infantum. Acta Crystallograph Sect F Struct Biol Cryst Commun. 62: 805-807

Vicente Miranda, H. , Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2005) Kinetic assay for measurement of enzyme concentration in situ. Analytical Biochemistry, 354:148-150.

Gomes, R., Sousa Silva, M., Vicente Miranda, H. , Ferreira, A.E.N., Cordeiro, C., Ponces Freire, A. (2005) Protein glycation in Saccharomyces cerevisiae : Argpyrimidine formation and methylglyoxal catabolism. FEBS Journal , 272(17): 4521-4531.

Abecasis, J.P.R., Ferreira, A.E.N., Vicente Miranda, H. , Gomes, R., Sousa Silva, M., Cordeiro, C., Ponces Freire, A. (2005) Parameter estimation in multi-enzyme systems using evolutionary algorithms. BKDB2005 – Bioinformatics: Knowledge Discovery in Biology . Faculdade de Ciências de Lisboa Ed. pp 48-52.

Sousa Silva, M. , Ferreira, A.E.N., Tomás, A.M., Cordeiro, C., Ponces Freire, A. (2005) Quantitative assessment of the glyoxalase pathway in Leishmania infantum as a therapeutic target by modelling and computer simulation. FEBS Journal 272(10): 2388-2398.

do Rosario PM , Cordeiro CA , Freire AP , Nogueira JM (2005) Analysis of methylglyoxal in water and biological matrices by capillary zone electrophoresis with diode array detection. Electrophoresis, 26(9):1760-1767.

Gomes, R., Sousa Silva, M. , Quintas, A., Cordeiro, C., Freire, A., Pereira, P., Martins, A., Monteiro, E., Barroso, E., Ponces Freire, A. (2005) Argpyrimidine, a methylglyoxal-derived advanced glycation end-product in familial amyloidotic polyneuropathy. Biochemical Journal 385: 339-345.

Ponces-Freire, A., Ferreira, A.E., Gomes, R. and Cordeiro, C. (2003) Antiglycation defences in yeast. Biochem. Soc. Trans. 31 : 1409-1412.

Ferreira, A.E., Ponces-Freire, A. and Voit, E.O. (2003) A quantitative model of the generation of N-e-carboxymethyl-lysine in the Maillard reaction between collagen and glucose. Biochem. J. 376 : 109-121.

Ahmed, N., Argirov, O., Minhas, H., Cordeiro, C. and Thornaley, P.J. (2002) Assay of advanced glycation endproducts (AGEs) by chromatographic assay with derivatisation by aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to N-e-carboxymethyl-lysine- and N-e-(1-carboxyethyl)lysine-modified albumin, Biochem. J. 364 : 1-14.

Martins, A., Mendes, P., Cordeiro, C. and Ponces Freire, A. (2001) In situ kinetic analysis of glyoxalase I and glyoxalase II in Saccharomyces cerevisiae, Eur. J. Biochem. 268 : 3930-3936.

Martins, A., Cordeiro, C. and Ponces Freire, A. (2001) In situ analysis of methylglyoxal metabolism in Saccharomyces cerevisiae , FEBS Letters, 499 : 41-44.

Martins, A., Cordeiro, C. and Ponces Freire, A. (1999) Glyoxalase II in Saccharomyces cerevisiae: In situ kinetics using the 5,5′-dithiobis(2-nitrobenzoic) acid assay, Arch. Biochem. Biophys. 366 : 15-20.

Voit, E.O. and Ferreira, A. (1998) Buffering in Models of Integrated Biochemical Systems, J. Theor. Biol. , 268 : 3930-3936.

Cordeiro, C. and Ponces Freire, A. (1996) Methylglyoxal assay in cells as 2-methylquinoxaline using 1,2-diaminobenzene as derivatizing reagent, Anal. Biochem. 234 : 221-224.

Cordeiro, C. and Ponces Freire, A. (1996) Methylglyoxal, glyoxalase I and oxidative stress, Biochem. Soc. Transactions. 24 : 472S.

Cordeiro, C. and Ponces Freire, A. (1995) Digitonin permeabilization of Saccharomyces cerevisiae cells for in situ enzyme assay, Anal. Biochem. 229 . 145-148.

Cordeiro, C. and Ponces Freire, A. (1994) Protein Determination in permeabilized yeast cells, Anal. Biochem. 223 . 321-323.

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